Colchicine is an alkaloid derived from plants.What is its effect on chromosome behavior?
A)By blocking DNA replication,chromosomes fail to migrate to the poles at anaphase; thus,homologous chromosomes end up in the same nucleus.
B)By blocking DNA replication,chromosomes do not undergo meiosis II and instead half the gametes are empty.
C)By blocking DNA replication,chromosomes do not undergo meiosis I and instead all gametes suffer from aneuploidy.
D)By interfering with spindle formation,replicated chromosomes fail to migrate to the poles at anaphase; thus,sister chromatids end up in the same nucleus.
E)By interfering with spindle formation,replicated chromosomes fail to migrate to the poles at anaphase; thus,homologous chromosomes end up in the same nucleus.

Question

Quizplus · Accepted Answer

Colchicine interferes with spindle formation, which leads to replicated chromosomes failing to migrate to the poles at anaphase. This results in sister chromatids ending up in the same nucleus, which can cause chromosomal abnormalities such as aneuploidy. Therefore, choice D is the best answer.

Colchicine Is an Alkaloid Derived from Plants