Which DNA methyltransferase DNMT)is important in maintaining DNA methylation patterns during DNA replication?

Question

Quizplus · Accepted Answer

DNMT1 is the DNA methyltransferase that is primarily responsible for maintaining DNA methylation patterns during DNA replication. It is able to recognize hemimethylated DNA (where only one strand is methylated) and restore the methylation on the newly synthesized strand. DNMT3a and DNMT3b are involved in de novo DNA methylation, where new methylation patterns are established, rather than maintaining existing patterns. DNMT2 has been shown to have tRNA methyltransferase activity, but not DNA methyltransferase activity. Therefore, the correct answer is choice A, DNMT1.

Which DNA Methyltransferase DNMT)is Important in Maintaining DNA Methylation Patterns