Collagenase (Santyl)is Ordered by the Physician for the Treatment of a Client

Collagenase (Santyl) is ordered by the physician for the treatment of a client with a stage III to IV sacral pressure ulcer.The nurse would do which of the following to use this agent appropriately?

A) Refrigerate the solution after use to maintain stability
B) Cleanse the wound area of debris by gentle irrigation with sterile normal saline before application of the solution
C) Use a mild soap to cleanse the wound before applying the agent
D) Use the agent with Burrow's solution or another acidic-type solution for maximal effects