Which of the following chemotherapeutic drugs is considered to be cell-cycle specific for the S phase of the cell life cycle?

Question

Quizplus · Accepted Answer

Methotrexate is a folate antagonist that targets the S phase of the cell cycle by inhibiting dihydrofolate reductase, which is essential for DNA synthesis. Asparaginase is an enzyme that targets cancer cells by breaking down the amino acid asparagine, but it does not have a specific cell cycle phase target. Bleomycin targets the G2 phase of the cell cycle by causing DNA breakage. Vincristine targets the M phase of the cell cycle by blocking the spindle apparatus that is responsible for separating chromosomes during cell division.

Which of the Following Chemotherapeutic Drugs Is Considered to Be