An antibody cannot stimulate the complement cascade unless it is attached to an antigen.

Name: An antibody cannot stimulate the complement cascade unless it is attached to an antigen.
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Quizplus · Accepted Answer

This is because the complement cascade requires activation through the binding of complement proteins to the Fc region of an antibody that is bound to an antigen. Without an antigen to bind to, the antibody cannot stimulate the complement cascade.

An Antibody Cannot Stimulate the Complement Cascade Unless It Is