How is glutamate important to pain pathways?
A) binds to AMPA receptors on dorsal horn cells
B) results in hypersensitivity of damaged tissue
C) causes P-substance release
D) binds to AMPA receptors on dorsal horn cells and results in hypersensitivity of damaged tissue
E) results in hypersensitivity of damaged tissue and causes P-substance release

Question

Quizplus · Accepted Answer

Glutamate is an important neurotransmitter in pain pathways as it binds to AMPA receptors on dorsal horn cells, which results in hypersensitivity of damaged tissue. Therefore, the correct answer is D. Option A is incorrect because it only mentions the binding of glutamate to AMPA receptors, ignoring its role in pain pathways. Option B and E are incorrect because they only mention the hypersensitivity of damaged tissue without mentioning the involvement of glutamate in the pathway. Option C is incorrect because glutamate causes the release of substance P and not the other way around.

How Is Glutamate Important to Pain Pathways