A balance of IPSPs and EPSPs will negate each other so that the grand postsynaptic potential is essentially unaltered.

Question

Quizplus · Accepted Answer

This statement is true. The inhibitory postsynaptic potentials (IPSPs) and excitatory postsynaptic potentials (EPSPs) work on opposite ends of the spectrum of depolarization and hyperpolarization. When they are balanced so that they cancel each other out, the overall effect on the postsynaptic neuron is negligible.

A Balance of IPSPs and EPSPs Will Negate Each Other