The hydrophobic interior of the lipid bilayer of the plasma membrane blocks the passage of water-soluble substances.

Name: The hydrophobic interior of the lipid bilayer of the plasma membrane blocks the passage of water-soluble substances.
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The hydrophobic interior of the lipid bilayer is impermeable to most water-soluble substances, as they cannot pass through the nonpolar interior. However, small nonpolar molecules, such as oxygen and carbon dioxide, can diffuse across the lipid bilayer.

The Hydrophobic Interior of the Lipid Bilayer of the Plasma