Growth hormone stimulates the liver to produce insulin-like growth factor (IGF-1), also called somatomedin, which mediates growth hormone's effects on bone growth. Growth hormone indirectly stimulates bone growth through somatomedin release rather than directly, and it does not promote closure of the epiphyseal plate.

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Growth Hormone

Question 74

Multiple Choice

Growth hormone

A) directly stimulates bone growth
B) exerts its effects on bones via somatomedin release
C) promotes closure of the epiphyseal plate
D) directly stimulates bone growth and promotes closure of the epiphyseal plate
E) exerts its effects on bones via somatomedin release and promotes closure of the epiphyseal plate

Correct Answer: