Lipophilic hormones circulate in the blood largely bound to plasma proteins.

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Lipophilic hormones, such as steroid hormones, are mostly insoluble in water and therefore require transport proteins to travel in the bloodstream. These transport proteins also help to protect the hormone from rapid metabolism and elimination by the liver and kidneys. The bound hormone can then dissociate from the protein when it reaches its target tissue, where it can exert its biological effects.

Lipophilic Hormones Circulate in the Blood Largely Bound to Plasma