The plasma clearance of a substance can be used to calculate the glomerular filtration rate (GFR) if that substance is freely filtered at the glomerulus and
A) secreted and reabsorbed by the tubules
B) neither reabsorbed nor secreted by the tubules
C) secreted by the tubules
D) reabsorbed by the tubules
E) none of these

Question

Quizplus · Accepted Answer

To accurately calculate GFR, the substance must be freely filtered at the glomerulus without any reabsorption or secretion by the tubules. This ensures that the clearance of the substance is solely dependent on the filtration rate at the glomerulus, which is equivalent to the GFR. Therefore, choice B (neither reabsorbed nor secreted by the tubules) is the best choice.

The Plasma Clearance of a Substance Can Be Used to Calculate