According to Map 3.1: Chesapeake Colonies in the Seventeenth Century,what river led most directly to the earliest established Chesapeake settlements?

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The James River is the most direct river that led to the earliest established Chesapeake settlements such as Jamestown and Williamsburg. The Potomac and Rappahannock Rivers were also important waterways for trade and transportation in the Chesapeake region, but they did not lead directly to the earliest settlements. The Susquehanna River is not shown on the map and is located farther north in Pennsylvania.