Why does the local and systemic absorption of topical anesthetics increase the risk of toxicity?

Question

Quizplus · Accepted Answer

Topical anesthetics can increase the risk of toxicity due to several factors: they often do not contain vasoconstrictors, which would otherwise slow their absorption into the bloodstream; they are formulated in high concentrations to ensure efficacy; and they can be absorbed quickly into the tissue and bloodstream, especially if the application area experiences vasodilation. All these factors contribute to a higher risk of systemic toxicity.

Why Does the Local and Systemic Absorption of Topical Anesthetics