What factor/factors influence(s)the duration of the effects of local anesthetics?

Question

Quizplus · Accepted Answer

All of the listed factors influence the duration of the effects of local anesthetics.

A) Degree of protein binding: Local anesthetics that are highly protein-bound have a longer duration of action because they are released slowly from the protein, prolonging their effect.

B) Vascularity of injection site: Areas with higher vascularity (more blood flow) will have a shorter duration of action because the anesthetic is quickly removed from the site by the bloodstream.

C) Addition or absence of a vasoconstrictor: Anesthetics combined with a vasoconstrictor such as epinephrine can prolong the effects by reducing blood flow to the injection site, slowing the removal of the anesthetic. On the other hand, the absence of a vasoconstrictor will result in a shorter duration of action.

Overall, considering all these factors together can help determine the most appropriate dose and delivery method to achieve the desired duration and level of anesthesia.

What Factor/factors Influence(s)the Duration of the Effects of Local Anesthetics