Which part of the chemical structure of a local anesthetic determines the pattern of biotransformation of the anesthetic?

Question

Quizplus · Accepted Answer

The intermediate chain of a local anesthetic determines the pattern of biotransformation of the anesthetic. The intermediate chain contains an amide or ester bond, which can be hydrolyzed by esterases or amidases in the body. The type of bond in the intermediate chain affects the susceptibility of the anesthetic to biotransformation and thus its duration of action. Lipophilic and hydrophilic parts of the chemical structure determine the anesthetic's solubility and absorption into tissues, but do not determine the pattern of biotransformation.

Which Part of the Chemical Structure of a Local Anesthetic