You Have Developed an Antibiotic That Inhibits a Bacterial Enzyme

You have developed an antibiotic that inhibits a bacterial enzyme critical for the formation of the cell wall. However, after only a short time, the bacteria become resistant to the antibiotic, and it's no longer effective. Which of the following may be a mechanism by which the bacteria are no longer sensitive to your antibiotic?

A) Over time, your antibiotic selected for bacteria containing a gene that codes for an enzyme capable of metabolizing your antibiotic.
B) The bacteria learned to avoid taking up the antibiotic in their surroundings.
C) The immune system of bacteria recognized the antibiotic as being foreign and quickly remove any antibiotic before it could accumulate to toxic levels.
D) Through the use of plasmids, bacteria communicated with other bacteria that a noxious chemical was present in the environment.