After Charles Darwin began suffering panic disorder, he lived in relative seclusion and traveled only in his wife's company. His panic disorder was apparently accompanied by

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Agoraphobia is a type of anxiety disorder characterized by a fear of being in situations where escape might be difficult or where help might not be available in case of a panic attack or other incapacitating or embarrassing symptoms. This fear often leads to avoidance of situations such as being in open or enclosed spaces or being in crowds, among other situations. It is likely that Darwin's panic disorder led to agoraphobia and subsequent seclusion.

After Charles Darwin Began Suffering Panic Disorder, He Lived in Relative