In a classic experiment, obese patients whose daily caloric intake was dramatically reduced lost only 6 percent of their weight. This limited weight loss was due, at least in part, to the fact that their dietary restriction led to a(n)

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When dietary intake is reduced, the body's metabolism may slow down in order to conserve energy, which can limit weight loss. This is likely what occurred in the case of the obese patients in the experiment. A decrease in ghrelin secretion (A) would actually be expected to decrease hunger and promote weight loss, while an elevation of set points (B) or blood glucose levels (D) would not directly affect weight loss in the same way as a decrease in metabolic rate.

In a Classic Experiment, Obese Patients Whose Daily Caloric Intake