Which of the following involves significant life disruption from the use of psychoactive drugs?

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Substance use disorder (previously known as addiction) involves significant life disruption from the use of psychoactive drugs, including cravings, withdrawal symptoms, and difficulty controlling use despite negative consequences. Reuptake refers to the reabsorption of neurotransmitters by the sending neuron, tolerance refers to the need for increasing amounts of a drug to achieve the same effect, and a near-death experience is a subjective experience often reported by individuals who have come close to death but survived.

Which of the Following Involves Significant Life Disruption from the Use