Social research indicates that a person is most likely to marry someone from the same village or city, or a high school or college classmate. Therefore, the Hardy-Weinberg equilibrium does not apply well to human populations because

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The Hardy-Weinberg equilibrium assumes random mating, which is not the case in human populations where people are more likely to marry someone from the same village/city or a classmate. This results in nonrandom mating, disrupting the equilibrium.

Social Research Indicates That a Person Is Most Likely to Marry