You Are Trying to Explain to a Friend the Concept

You are trying to explain to a friend the concept of the vicious cycle of depression. To which mutual acquaintance will you refer to illustrate the concept?

A) Sandra, who has felt worthless ever since she dropped out of university, and has been so depressing to be around that some of her friends have avoided her.
B) Joe, who dropped out of college last year because he didn't feel he fit in, and he's been looking for work ever since.
C) Mike, whose girlfriend left him a few months ago.
D) Rasheeda, who had a huge fight with her mother, lost her job, and then sprained her ankle.