When a law or regulation of the federal government directly conflicts with those of a U.S.state or local government,the federal law will generally prevail.This is known as:

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Federal preemption refers to the power of the federal government to override state or local laws when there is a direct conflict. This is based on the Supremacy Clause of the U.S. Constitution, which establishes that federal law is supreme over state law. Thus, in cases of conflict, the federal law will generally prevail, and this is known as federal preemption.

When a Law or Regulation of the Federal Government Directly