The nurse is administering two drugs to a patient and learns that both drugs are highly protein-bound. The nurse may expect

Question

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When drugs are highly protein-bound, there is limited availability of free drug in the circulation for therapeutic activity. This can increase the risk of adverse effects as the bound drug can be displaced from protein binding sites and lead to an increase in free drug concentration. This can result in toxicity or other adverse effects. Therefore, the nurse may expect an increased risk of adverse effects when administering highly protein-bound drugs.

The Nurse Is Administering Two Drugs to a Patient and Learns