While running a CBC on the hematology analyzer, the platelet count is flagged for thrombocytopenia and possible interference. On reviewing the peripheral smear, many grapelike clusters are noted on the smear. What is your next step?

Question

Quizplus · Accepted Answer

The presence of grapelike clusters on the peripheral smear suggests platelet clumping, which can interfere with accurate platelet counting on automated hematology analyzers. Recollecting the CBC in sodium citrate and multiplying the platelet count by 1.1 before reporting the result can help correct for the presence of platelet clumps and provide a more accurate platelet count. Rejecting the specimen or reporting the CBC with no additional action may not provide accurate results for the patient. Recollecting the CBC in sodium heparin may not improve the accuracy of the platelet count, as heparin may also interfere with platelet counting.

While Running a CBC on the Hematology Analyzer, the Platelet