In reference to detecting minimal residual disease, which of the following is true?

Question

Quizplus · Accepted Answer

qPCR, or quantitative polymerase chain reaction, is the most sensitive technique for detecting low levels of minimal residual disease. PCR, karyotyping, and Southern blot analysis all have varying levels of sensitivity and specificity, but qPCR has become the gold standard due to its high sensitivity and ability to quantify the amount of residual disease present. Karyotyping is not typically sensitive enough to detect low levels of residual disease, with a limit of detection of around 5-10% tumor burden, and Southern blot analysis is not as widely used due to the advent of more advanced molecular techniques.

In Reference to Detecting Minimal Residual Disease, Which of the Following