Which cytochemical stain is useful in differentiating CML from a leukemoid reaction?

Question

Quizplus · Accepted Answer

The LAP stain is useful in differentiating chronic myelogenous leukemia (CML) from a leukemoid reaction. In CML, LAP activity is decreased or absent, while in a leukemoid reaction, LAP activity is increased. A leukemoid reaction is a reactive increase in leukocyte count due to an acute infection or inflammation, while CML is a type of leukemia characterized by the abnormal production of cells in the bone marrow. The other cytochemical stains listed (PAS, MPO, TRAP) are not specifically helpful in differentiating CML from a leukemoid reaction.

Which Cytochemical Stain Is Useful in Differentiating CML from a Leukemoid