It Has Been Determined That a Patient Has Activated Protein

It has been determined that a patient has activated protein C resistance. Name the most prevalent genetic mutation associated with this finding.

A) Guanine to adenine substitution on nucleotide 20210 of the prothrombin gene
B) Lysine to glutamic acid substitution on the sixth position on the beta globin chain
C) Arginine to glutamine substitution at the 506 position of factor V protein
D) Translocation of chromosome 22 onto the long arm of chromosome 9