A patient, 2 years of age, presents with general fatigue, pallor, fever, and weight loss. The morphological exam reveals a normal leukocyte count, marked neutropenia, and thrombocytopenia with 35% blasts. A bone marrow smear reveals hypercellularity with neoplastic lymphoid cells. What immunophenotypic testing would be indicated for this patient?

Question

Quizplus · Accepted Answer

The presentation of the patient is consistent with acute lymphoblastic leukemia (ALL), which is characterized by neoplastic lymphoid cells. Immunophenotyping is crucial in determining the specific subtype and guiding treatment. The markers CD2, CD3, CD5, CD7, and CD19 are commonly used in the diagnosis of ALL and would be appropriate for this patient. CD33 and CD34 are markers commonly used in acute myeloid leukemia (AML), CD11c and CD117 are markers for mast cell disorders, and CD19, CD20, CD22, and Ig genes are markers for B-cell lymphoma/leukemia.

A Patient, 2 Years of Age, Presents with General Fatigue