A patient presents with a morphological smear examination revealing 20% blasts with prominent granules and Auer rods, MPO, and SBB positive. A 25% monocyte count was seen in the peripheral smear. There were no recurrent cytogenetic abnormalities observed. Under which classification of acute leukemia, not otherwise specific, does this diagnosis fall?

Question

A patient presents with a morphological smear examination revealing >20% blasts with prominent granules and Auer rods, MPO, and SBB positive. A 25% monocyte count was seen in the peripheral smear. There were no recurrent cytogenetic abnormalities observed. Under which classification of acute leukemia, not otherwise specific, does this diagnosis fall?

Quizplus · Accepted Answer

The presence of >20% blasts with Auer rods and positive for both MPO and SBB indicates a myeloid lineage. The presence of 25% monocytes demonstrates monocytic differentiation. This combination of features fits the criteria for acute myelomonocytic leukemia. The lack of recurrent cytogenetic abnormalities rules out Acute myeloblastic leukemia without maturation and Acute erythroid leukemia. Acute panmyelosis with myelofibrosis is a rare form of acute leukemia that involves myeloid, erythroid, and megakaryocytic involvement with bone marrow fibrosis.

A Patient Presents with a Morphological Smear Examination Revealing >20