A patient presents with bleeding and is found to be in DIC. The peripheral smear contains hypergranular promyelocytes. The white count is slightly elevated. The bone marrow contains cells with multiple Auer rods with a clear blue cytoplasm. What is the probable type of AML?

Question

Quizplus · Accepted Answer

The presence of hypergranular promyelocytes and cells with multiple Auer rods in the context of acute myeloid leukemia (AML) suggests a diagnosis of AML with t(15;17)(q22;q12), which is characteristic of acute promyelocytic leukemia (APL). This subtype is specifically associated with the t(15;17) translocation, leading to the PML-RARA fusion gene, a hallmark of APL.

A Patient Presents with Bleeding and Is Found to Be