A patient presents with 25% blasts (nonerythroid), 34% monocytic cells, and 31% granulocytic cells in the bone marrow. The peripheral blood smear has 10% monocytes. The alpha-naphthyl esterase and chloroacete esterase are positive. What is the probable diagnosis based on these findings?

Question

Quizplus · Accepted Answer

The combination of monocytic and granulocytic cells in the bone marrow, along with positive alpha-naphthyl esterase and chloroacetate esterase, suggests a diagnosis of acute myelomonocytic leukemia (AMML). The presence of 25% blasts further supports a diagnosis of acute leukemia. Option A, acute monocyte leukemia, is not a recognized subtype of acute leukemia. Option B, acute monoblastic leukemia, would have a higher percentage of blasts (typically >80%) and a lower percentage of granulocytic cells. Option D, acute erythroid leukemia, would have a predominance of erythroid precursors in the bone marrow and possibly in the peripheral blood.

A Patient Presents with 25% Blasts (Nonerythroid), 34% Monocytic Cells