Which is found in 90% of cases of PV and promotes EPO receptor activation?

Question

Which is found in >90% of cases of PV and promotes EPO receptor activation?

Quizplus · Accepted Answer

JAK2(V617F) is found in over 90% of cases of PV and promotes EPO receptor activation, leading to the proliferation of erythrocyte precursors and the overproduction of red blood cells. Bcl-x₁ is not relevant to PV. BCR/ABL1 is associated with chronic myeloid leukemia (CML) and RAS mutations are associated with other myeloproliferative neoplasms such as chronic myelomonocytic leukemia.

Which Is Found in >90% of Cases of PV and Promotes