A neutrophil contains many giant gray-green peroxidase-positive bodies and giant lysosomes. Which of the following anomalies is associated with these findings?

Question

Quizplus · Accepted Answer

The giant gray-green peroxidase-positive bodies and giant lysosomes are characteristic of Chédiak-Higashi syndrome, which is an autosomal recessive disorder that affects the lysosomal trafficking regulator gene. This results in abnormal lysosome formation and function. May-Hegglin syndrome is characterized by thrombocytopenia and giant platelets, not neutrophil anomalies. Pelger-Huët anomaly is characterized by bilobed or peanut-shaped neutrophil nuclei and does not involve lysosomal abnormalities. Alder-Reilly anomaly is characterized by large, purple-staining granules in lymphocytes and plasma cells, not neutrophils.

A Neutrophil Contains Many Giant Gray-Green Peroxidase-Positive Bodies and Giant