The underlying cause of TTP is:
A) An unregulated coagulation cascade
B) Deficiency in VWF multimers
C) Deficiency of ADAMTS-13 protease
D) Overproduction of cryoprecipitate

Question

Quizplus · Accepted Answer

TTP is caused by deficiency or dysfunction of ADAMTS-13 protease, which normally cleaves large VWF multimers in the bloodstream. Without ADAMTS-13, large VWF multimers accumulate and form platelet clumps, leading to thrombocytopenia and microvascular thrombosis.

The Underlying Cause of TTP Is