Which two proteins are critical for the effective function of the G1 checkpoint?
A) Cdk4 and Cdk6
B) Cyclin E
C) P21 and p57
D) P53 and Rb

Question

Quizplus · Accepted Answer

The two critical proteins for the effective function of the G1 checkpoint are P53 and Rb. P53 is a tumor suppressor protein that can halt the cell cycle in response to DNA damage or other stress factors, while Rb (retinoblastoma protein) plays a key role in regulating the G1-S transition by inhibiting the activity of E2F transcription factors, which promote cell cycle progression. Together, P53 and Rb help to ensure that cells with damaged DNA or other abnormalities do not progress through the cell cycle, which helps to prevent the development of cancer.

Which Two Proteins Are Critical for the Effective Function of the G1