Paroxysmal cold hemoglobinuria is confirmed by a positive:

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Paroxysmal cold hemoglobinuria is confirmed by a positive Donath-Landsteiner test. This test detects the presence of antibodies directed against the P antigen on red blood cells that activate complement and cause hemolysis, which is characteristic of paroxysmal cold hemoglobinuria. Antibody class IgM and cold agglutinin test are also associated with cold autoimmune hemolytic anemia but not specific for paroxysmal cold hemoglobinuria. Thermal amplitude of antibody over 20°C is not relevant in the diagnosis of this condition.

Paroxysmal Cold Hemoglobinuria Is Confirmed by a Positive