The SAO variant of HE is associated with:
A) Defective pectrin tetramer formation
B) Defective protein 4.1
C) Defective band 3 protein and abnormally tight binding to ankyrin
D) All of the above

Question

Quizplus · Accepted Answer

The SAO variant of HE is caused by a defect in the band 3 protein, which leads to abnormally tight binding to ankyrin. This affects the stability and integrity of the red blood cell membrane, leading to hemolytic anemia. There is no known association with defective pectrin tetramer formation or defective protein 4.1.

The SAO Variant of HE Is Associated With