Recent evidence suggests that the pathophysiology of most cases of acquired aplastic anemia is most likely:
A) Drug exposure
B) Viral infections
C) Defective stem cells
D) Immunologic suppression of hematopoiesis

Question

Quizplus · Accepted Answer

Acquired aplastic anemia is characterized by bone marrow failure due to immune-mediated suppression of hematopoiesis. While drug exposure and viral infections can contribute to the development of the disease, the underlying mechanism involves the destruction of hematopoietic stem cells by autoreactive T cells.

Recent Evidence Suggests That the Pathophysiology of Most Cases of Acquired