Impaired alpha chain production in alpha thalassemias causes:

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Impaired alpha chain production in alpha thalassemias leads to the formation of abnormal hemoglobin types, specifically Hb Bart's and Hb H. This is due to the accumulation of beta-globin chains and the formation of tetramers with gamma and delta chains in Hb Bart's, and tetramers with beta chains in Hb H. Overproduction of hemoglobin F and A2 is not a characteristic of alpha thalassemias, and fusion of alpha and gamma chains does not occur. Normal hemoglobin distribution is also affected in alpha thalassemias due to the production of abnormal hemoglobin types.

Impaired Alpha Chain Production in Alpha Thalassemias Causes