The net decrease in negative charge in the hemoglobin S molecule is responsible for which laboratory finding?
A) Increase in solubility
B) Change in the electrophoretic mobility
C) Increase in oxygen infinity
D) Increase in flexibility of the red blood cell

Question

Quizplus · Accepted Answer

The net decrease in negative charge in the hemoglobin S molecule leads to a change in its electrophoretic mobility, which is the movement of charged particles in an electric field. This can be seen on an electrophoresis gel, where hemoglobin S migrates differently than normal hemoglobin A due to its altered charge.

The Net Decrease in Negative Charge in the Hemoglobin S