The main disadvantage of a factorial design is that the number of treatment combinations increases multiplicatively with an increase in the number of variables or levels.

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Quizplus · Accepted Answer

This is true, as the number of treatment combinations equals the product of the number of levels of each variable. This can lead to impractical or unfeasible study designs when dealing with a large number of variables or levels.

The Main Disadvantage of a Factorial Design Is That the Number