Which manifestation differentiates primary syphilis from secondary syphilis?

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The appearance of a chancre (a firm, painless, ulcerated lesion) is characteristic of primary syphilis and typically appears 2-3 weeks after infection. In secondary syphilis, a widespread rash and flu-like symptoms (fever, headache, malaise) are characteristic manifestations that typically appear 2-10 weeks after the chancre has resolved. Serologic testing can be used to diagnose syphilis at any stage of the infection.

Which Manifestation Differentiates Primary Syphilis from Secondary Syphilis