Most congenital anomalies of the central nervous system (CNS)result from defects in the closure of the neural tube during fetal development.Which factor has the greatest impact on this process?

Question

Quizplus · Accepted Answer

Maternal folic acid deficiency has the greatest impact on the closure of the neural tube during fetal development. Adequate folic acid intake before and during early pregnancy can prevent up to 70% of neural tube defects. Maternal diabetes and use of anticonvulsants may increase the risk of neural tube defects, but folic acid deficiency is the most significant factor. Socioeconomic status may also be a risk factor but it is not the most significant factor.

Most Congenital Anomalies of the Central Nervous System (CNS)result from Defects