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What Is the Role of Titanium Chloride in the Mukaiyama

Question 5

Multiple Choice

What is the role of titanium chloride in the Mukaiyama reaction shown below? What is the role of titanium chloride in the Mukaiyama reaction shown below?   A) Titanium activates the aldehyde electrophile,and a chloride ion removes the sialyl-containing TMS group. B) Titanium activates the alkene electrophile,and a chloride ion removes the sialyl-containing TMS group. C) Titanium activates the aldehyde electrophile,and a chloride ion forms an ion pair with the carbocation intermediate. D) Titanium removes the sialyl-containing TMS group,and the chloride ion activates the aldehyde nucleophile.


A) Titanium activates the aldehyde electrophile,and a chloride ion removes the sialyl-containing TMS group.
B) Titanium activates the alkene electrophile,and a chloride ion removes the sialyl-containing TMS group.
C) Titanium activates the aldehyde electrophile,and a chloride ion forms an ion pair with the carbocation intermediate.
D) Titanium removes the sialyl-containing TMS group,and the chloride ion activates the aldehyde nucleophile.

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