Strong amide bases like LDA favour the formation of Z enolates.

Name: Strong amide bases like LDA favour the formation of Z enolates.
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Question

Quizplus · Accepted Answer

Strong amide bases like LDA (lithium diisopropylamide) deprotonate the acidic alpha carbon of a carbonyl compound to form an enolate intermediate. This enolate intermediate can exist in both E and Z forms, but strong amide bases preferentially stabilize the Z enolate due to the bulkiness of the non-polar isopropyl groups.

Strong Amide Bases Like LDA Favour the Formation of Z