The rate-determining step of a nucleophilic acyl substitution reaction is the formation of the tetrahedral intermediate.

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In a nucleophilic acyl substitution reaction, the rate-determining step is the formation of the tetrahedral intermediate, as this is the step that involves the breaking of the carbonyl bond and the formation of a new bond between the nucleophile and the carbonyl carbon.

The Rate-Determining Step of a Nucleophilic Acyl Substitution Reaction Is