The removal of a sample of tissue from a large lesion to diagnose or determine the extent of a disease is known as:

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An incisional biopsy involves removing a small piece of tissue from a larger lesion or tumor to diagnose or determine the extent of a disease. This is different from an excisional biopsy, which involves removing the entire lesion or tumor. Exfoliative cytology involves collecting cells from a surface area, such as the cervix, without removing tissue. Brush biopsy involves collecting cells from a mucosal surface using a brush-like instrument. However, neither of these methods involves removing tissue from a large lesion.

The Removal of a Sample of Tissue from a Large