Local tissue invasion is the step that signifies a change from a precancerous neoplasm to a malignant one.

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Local tissue invasion is a hallmark of malignant tumors, indicating the ability of cancer cells to invade surrounding tissues and organs. In contrast, precancerous neoplasms are generally confined to a specific area or layer of tissue and do not invade neighboring structures. Therefore, local tissue invasion is a key step in the progression of cancer from a precancerous state to a malignant one.

Local Tissue Invasion Is the Step That Signifies a Change