Most clinical laboratories estimate the LDL-C using the Friedewald equation from individuals who are overnight fasted.What parameter is used to complete this equation (fill in the blank)? LDL-C=TC−[HDL-C+(0.20×______)]

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The Friedewald equation uses the parameter of triglycerides to estimate LDL-C. The equation assumes that VLDL-C (very low-density lipoprotein cholesterol) is equal to 0.20 multiplied by the triglyceride concentration. Therefore, the equation subtracts out an estimate of VLDL-C (0.20 x triglyceride concentration) from the total cholesterol to arrive at a calculated LDL-C value. This method is widely used in clinical laboratories to estimate LDL-C levels.

Most Clinical Laboratories Estimate the LDL-C Using the Friedewald Equation