The advantage of using doubly labeled water to measure energy expenditure is that it is ideally suited for use in free-living subjects.

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Doubly labeled water is a non-invasive technique that can be used to measure energy expenditure in free-living subjects. It involves the administration of water doubly labeled with stable isotopes of hydrogen and oxygen, which allows for the measurement of the rate of carbon dioxide production and thus energy expenditure over a period of days or weeks. Because it is non-invasive and requires no changes to the subject's usual behavior or routine, it is ideally suited for use in free-living subjects.

The Advantage of Using Doubly Labeled Water to Measure Energy